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Correlation of radiotherapeutic parameters and treatment related morbidity—analysis of RTOG study 77-06

Identifieur interne : 00E712 ( Main/Exploration ); précédent : 00E711; suivant : 00E713

Correlation of radiotherapeutic parameters and treatment related morbidity—analysis of RTOG study 77-06

Auteurs : M. V. Pilepich [États-Unis] ; S. O. Asbell [États-Unis] ; J. M. Krall [États-Unis] ; W. H. Baerwald [États-Unis] ; W. T. Sause [États-Unis] ; P. Rubin [États-Unis] ; B. N. Emami [États-Unis] ; G. M. Pidcock [États-Unis]

Source :

International Journal of Radiation Oncology, Biology, Physics [ 0360-3016 ] ; 1987.

RBID : ISTEX:8DD4DF624243495F95530F3BE70AA79D1A8C69E4

Abstract

The current report is an updated and detailed analysis of treatment related morbidity in RTOG 77-06, a Phase III randomized study comparing prostatic irradiation versus pelvic irradiation followed by a prostatic boost, in patients with Stage A2 and B carcinoma of the prostate without evidence of nodal involvement. A total of 453 analyzable cases were accrued from 1978 to 1983, when the study was closed. All cases of treatment related morbidity were classified as to severity (using a clinical severity grading system). The data were then correlated with a number of radiotherapeutic parameters including treatment volumes (fields), doses, and techniques. Overall, pelvic irradiation, compared to prostate irradiation only, was not associated with a significantly increased incidence of treatment related morbidity. Within the range of pelvic doses used in this study a significant dose effect could not be detected. Total doses to the prostate of more than 7000 cGy were associated with an increased risk of rectal bleeding. Certain treatment techniques, (APPA irradiation of the pelvic lymphatics) were associated with an increased incidence of bowel complications.

Url:

https://api.istex.fr/document/8DD4DF624243495F95530F3BE70AA79D1A8C69E4/fulltext/pdf

DOI: 10.1016/0360-3016(87)90038-1

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">The current report is an updated and detailed analysis of treatment related morbidity in RTOG 77-06, a Phase III randomized study comparing prostatic irradiation versus pelvic irradiation followed by a prostatic boost, in patients with Stage A2 and B carcinoma of the prostate without evidence of nodal involvement. A total of 453 analyzable cases were accrued from 1978 to 1983, when the study was closed. All cases of treatment related morbidity were classified as to severity (using a clinical severity grading system). The data were then correlated with a number of radiotherapeutic parameters including treatment volumes (fields), doses, and techniques. Overall, pelvic irradiation, compared to prostate irradiation only, was not associated with a significantly increased incidence of treatment related morbidity. Within the range of pelvic doses used in this study a significant dose effect could not be detected. Total doses to the prostate of more than 7000 cGy were associated with an increased risk of rectal bleeding. Certain treatment techniques, (APPA irradiation of the pelvic lymphatics) were associated with an increased incidence of bowel complications.</div>
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Correlation of radiotherapeutic parameters and treatment related morbidity—analysis of RTOG study 77-06

Correlation of radiotherapeutic parameters and treatment related morbidity—analysis of RTOG study 77-06

Source :

Abstract

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